Advantages in application
The hydrogel is used as advanced drug delivery vehicle.
The polymer solution is fluid at room temperature and can be mixed with active components and applied by subcutaneous injection. After injection the polymer rapidely turns into a solid hydrogel at body temperature, forming an advanced drug delivery depot.
Targets of this therapy approach are peripheral antigen-presenting cells (APC) of skin including macrophages, dermal dendritic cells and Langerhans cells.
These cells are modulated by the active components of the hydrogel (e.g. peptide loaded PS-liposomes) to act as tolerogenic cells, capable of inducing antigen-specific tolerance in T cells, turning naive or even differentiated T cells into regulatory T cells.